1The incidence and range of IEM as a cause of developmental

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The commoner causes of developmental delay are chromosomal abnormalities and structural brain abnormalities.2 One of the challenging questions for paediatricians investigating children with developmental delay is how intensively should one investigate canada goose outlet 80 off for inborn errors of metabolism and which metabolic investigations are indicated.Reports on the prevalence of inborn errors of metabolism (IEMs) as a href="https://www.yokosukabase.com" rel="friend"cheap canada goose/a the underlying cause of delay show some variation but generally indicate that IEMs are found to be the cause in only a small percentage of these cases3 (that is, 1 5%). In fact the American College of Medical Genetics in 1997 recommended omitting metabolic screening in unselected cases of developmental delay.3 The report from the American Academy of Neurology and the Practice Committee of the Child Neurology Society offers guidelines based on a review of published literature. 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